Subijanto Marto Sudarmo, Haryudi Aji Cahyono, Pitono Soeparto, Liek Djupri, Reza Ranuh.
CHILD HEALTH DEPARTMENT AIRLANGGA UNIVERSITY / SOETOMO HOSPITAL SURABAYA - INDONESIA
ABSTRACT:
Infection of pathogenic bacterial in diarrhea will result in the changes of intestinal micro ecology and the defense mechanism of intestinal microbe colonization, in order to overcome the disadvantaging process, reversal of intestinal flora integrity back to normal is necessary that could be done by making an improvement to the normal defense of microorganism colonization. Imbalance of intestinal microflora lead to the occurrence of diarrhoea. Manipulation by combining probiotics and prebiotics (synbiotic) is able to the improvement of clinical course of acute diarrhoea.
Objective: To manipulate the clinical course of acute diarrhoea in children (the remission rate and duration of remission) with the administration of synbiotic.
Mehtodology: Children age between 6 months to 2 years suffering from acute diarrhoea, were alocated for study using experimental design, randomized double blind placebo control clinical trial. The patients were randomly assigned into synbiotic group and control group.
Result and Discussion: 25 children in synbiotic group and 25 in control group. No differences in subject characteristic and confounding variables were found in both groups. At the synbiotic group, a more rapid improvement in the remission rate was significant compared to control group (p = 0.002). Similar result also was shown in the analysis of fecal form and frequency of daily fecal excretion where there was a significant decrease in the synbiotic group. Mean of duration of remission in the synbiotic group was 37 hours in which it was significantly different when compared to control group of 72 hours
Conclusion: The administration of synbiotic in acute diarrhoeal patients can rapidly improve the remission rate and duration of remission in order to shorten and prevent further transmission of pathogen.
